Analysis of Blood Group Parameters as an Early and Minimally Invasive Method for Susceptibility Prediction of Oral Squamous Cell Carcinoma

Aim: The purpose of this study was to evaluate the correlation between ABO blood grouping and oral squamous cell carcinoma and to stratify the patients in accordance with the susceptibility as noted.

Materials and Methods: This retrospective study included the demographic data of the patients having reported to the Department of Oral and Maxillofacial Surgery, Yenepoya Dental College and hospital, and Department of Oncology, Yenepoya Medical college and Hospital, Mangalore, Karnataka between January 2017 to December 2021. A total of 161, histopathologically proven oral squamous cell carcinoma patients, between the above time frame of 5 years, were recruited and were analyzed for the study.

Results: Patients with A Rh positive blood group had the maximum enrollment (80 patients out of 161) i.e. 49.6%, followed by an equal share of O Rh positive and B Rh positive with 31 each, i.e. 19.25% of each group. Only 8 patients had AB Rh positive blood group, followed by O Rh negative in 6 patients, A Rh negative in 3 patients, and least of B Rh negative blood group in only 2 patients.

Conclusion: Our study reflects that as simple as a blood group test, a routine and a regularly followed investigation, can help to sought and stratify the patients, with oral squamous cell carcinoma, who already are on a higher spectrum of falling under the radar of malignancy susceptibility.