A Case Report on Gastric Xanthelasma

Xanthelasmas of the gastrointestinal tract are rare. Gastric xanthelasmas (GX) are benign clusters of lipid-laden-macrophages present in lamina propria of the gastric mucosa. We present a case of a 44-year-old female who presented with complaints of upper abdominal discomfort, bloating and fatigue. On evaluation she had anemia. Esophagogastroduodenoscopy revealed GX, without pathological evidence of concomitant Helicobacter pylori infection. Though the exact pathogenesis of GX is not known, it is commonly associated with dyslipidemia, Helicobacter pylori infection-related chronic gastritis, hyperplastic gastric polyps, intestinal metaplasia, diabetes mellitus and synchronous or metachronous gastric cancer. A review of literature describing common clinicopathologic differentials of GX is presented after the case discussion.