Metal Based α-glucosidase Inhibitors: Synthesis, Characterization and α-glucosidase Inhibition Activity of Transition Metal Complexes

Aims: The aim of current study to examine percentage inhibition of α-glucosidase by synthesized transition metal complexes of 1,6-diaminohexane.

Study Design: Current study is based on given experimental methodology.

Place and Duration of Study: Faculty of Science and Environment and Department of Physical Sciences, between June 2009 and July 2010.

Methodology: In current work we have synthesized metal complexes by various salts of Co(II), Cu(II), Ni(II) and Zn(II) with 1,6-diaminohexane and characterized by means of infrared and ultraviolet spectroscopy. α-glucosidase inhibition activity has performed by standardize method of Tripathi et al. and calculated their IC50 value.

Results: All synthesized metal complexes of 1,6-diaminohexane are showing α-glucosidase inhibition activity among them [Zn(dahe)3]2Cl having highest α-glucosidase inhibition activity with lowest IC50 value 1.196 mg/ml while [Ni(dahe)3]2Cl having lowest α-glucosidase inhibition activity with highest IC50 value 3.633 mg/ml.

Conclusion: α-glucosidase inhibitors are oral antidiabetic drugs, which are widely used as chemotherapeutic agents in the clinical treatment of diabetes and obesity. Synthetic α-glucosidase inhibitor may be effective for antidiabetic treatment and other disorders because it is easy to synthesize and also having a great possibility to inhibit α-glucosidase. We have performed in-vitro α-glucosidase inhibition activity of transition metal complexes of 1,6-diaminohexane; however, need further work to validate reliability.